Cardiorespiratory Exercise Laboratory
Directors: Timothy I Musch, Ph.D. and David C Poole, Ph.D.
Improving oxygen transport during physical activity
Depending on age or health the limits to muscle O2 delivery and utilization will change. We explore these limitations in the lungs (emphysema, COPD), cardiovascular and muscular systems (heart failure, diabetes). Our work has pioneered new models of metabolic control, cardiovascular function and muscle microvascular oxygen delivery (capillary function) driving therapeutic solutions. Rats are often the preferred model of heart failure, aging, and diabetes whereas animals as diverse as elephants, racehorses, greyhound dogs and hamsters have made possible discoveries in lung function, hemodynamics and O2 exchange. This laboratory houses state-of-the-art animal exercise, intravital microscopy and phosphorescence quenching technology and has won more than 6.0 million dollars in funding.
Recumbent elephants lower arterial blood O2 pressures but maintain O2 saturation allowing safe surgical anesthesia
Race horses bleed into their lungs (exercise-induced pulmonary hemorrhage, EIPH). Nasal trips lower EIPH and preserve lung function
|Nitric oxide promotes increased blood flow to exercising muscles and dysfunction in this pathway helps explain decreased exercise function in aging and heart failure||Heart failure afflicts over 6 million Americans and decreases the number of capillaries that support blood flow. Major therapeutic initiatives are underway to reverse this effect (see below)|
Recent Research Presentations:Strolling Along the Oxygen Transport Pathway (pdf)
Lab Contact Information:
Timothy I. Musch, Ph.D. firstname.lastname@example.org or
David C. Poole, Ph.D. email@example.com
Clarenburg Research Laboratory
College of Veterinary Medicine
122 Coles Hall
1620 Denison Ave.
Kansas State University
Manhattan, KS 66506